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Updated: Jul 15, 2026

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
Published on: January 10, 2025
[Modern concept for treatment of the female-to-male transsexual]
J Dabernig1, O Schumacher, C Lenz
1Abteilung für Hand-, Mikro- und Plastische Chirurgie, Amper-Kliniken AG, Klinikum Dachau, Dachau, Germany.
Background:
The experience of our multidisciplinary team in surgical treatment of female-to-male trans-sexualism is presented, and our treatment concepts described in detail. In addition, our preferred technique of neourethra formation using a prefabricated free fibula flap is described.
Patients And Method:
From 1996 to 2003, thirty-four patients underwent gender reassignment surgery as a staged procedure. The neourethra was constructed using an anterior vaginal flap and the prefabricated free fibular flap.
Results:
There were four complete losses of the prefabricated fibular flap (11.7%). The neourethra stricture rate was 20.5% and the fistula formation rate was 14.7%. In 82.3% of the patients, the ability to micturate while standing was achieved.
Conclusion:
This modern concept reduces the complication rate and improves the quality of patient outcome.
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