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Updated: Jul 15, 2026
07:11
Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
Published on: May 25, 2020
[Positive ibopamine provocative test in normal-tension glaucoma suspects].
C Kniestedt1, T Romppainen, B P Gloor
1Augenklinik, Kantonspital Winterthur, Winterthur, Schweiz. christoph.kniestedt@usz.ch
Klinische Monatsblatter Fur Augenheilkunde
|April 27, 2007
Summary
Ibopamine eye drops can identify early glaucoma by causing a significant intraocular pressure increase in susceptible eyes. This test helps distinguish normal outflow from resistance, aiding in early detection of ocular hydrodynamic disorders.
Area of Science:
- Ophthalmology
- Ocular Physiology
Background:
- Ibopamine, an alpha-adrenergic agent, elevates intraocular pressure (IOP) in eyes with increased outflow resistance.
- It is a potential diagnostic tool for early ocular hydrodynamic disorders.
Purpose of the Study:
- To evaluate the efficacy of ibopamine 2% eye drops in detecting early glaucoma in normal-tension glaucoma suspects.
- To differentiate eyes with normal trabecular outflow capacity from those with increased resistance.
Main Methods:
- 64 normal-tension glaucoma suspect eyes were tested with ibopamine 2% eye drops.
- Intraocular pressure was monitored using applanation and contour tonometry before and after instillation.
- A positive test was defined as an IOP increase greater than 2.0 mmHg.
Main Results:
- 50% of eyes showed a positive pressure response to ibopamine.
- The positive test group exhibited a significant IOP increase (18.04 to 22.06 mmHg) and increased ocular pulse amplitude.
- No significant difference in central corneal thickness was observed between positive and negative test groups.
Conclusions:
- Ibopamine 2% eye drops effectively identify eyes with increased trabecular meshwork resistance.
- The test aids in differentiating eyes prone to pressure peaks and glaucoma development.
- Ibopamine shows promise for early detection of glaucoma in normal-tension glaucoma suspects.
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