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Related Experiment Video

Updated: Jul 15, 2026

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

First clinical experience with anecortave acetate (Retaane).

S Hayek¹, M Scherrer, D Barthelmes

¹Augenklinik, UniversitätsSpital, Zürich, Switzerland.

Klinische Monatsblatter Fur Augenheilkunde

|April 27, 2007

Summary

Anecortave acetate injections for age-related macular degeneration (AMD) showed a favorable safety profile. While visual acuity varied, many patients maintained stable vision, suggesting potential as a less invasive treatment option.

Related Experiment Videos

Last Updated: Jul 15, 2026

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

Area of Science:

Ophthalmology
Retinal Diseases
Pharmacology

Background:

Anecortave acetate is an angiostatic corticosteroid used for exudative age-related macular degeneration (AMD).
It is administered via posterior juxtascleral depot injection.
Currently not approved in Switzerland, it's available under compassionate use.

Purpose of the Study:

To evaluate the safety and efficacy of anecortave acetate in treating exudative AMD.
To assess changes in visual acuity and adverse events following treatment.

Main Methods:

An uncontrolled case series involving 22 eyes of 19 patients.
Standardized documentation of ETDRS visual acuity, near acuity, magnification needs, and fluorescein angiography.
Treatment involved a posterior juxtascleral depot injection of 15 mg anecortave acetate.

Main Results:

The mean change in visual acuity after 3 months was -2.6 ETDRS letters.
15/20 eyes showed stable vision or gained vision.
5/20 eyes experienced moderate vision loss, and 1/20 experienced significant vision loss.
No moderate or severe adverse events were reported.

Conclusions:

Posterior juxtascleral depot injection of 15 mg anecortave acetate is safe and well-tolerated.
It may serve as an alternative therapeutic option for eyes with occult CNV or residual neovascular activity post-photodynamic therapy.
Its less invasive nature and lower risk profile make it a viable consideration before anti-VEGF agents.