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Desymmetrization of 1,4-cyclohexadienyltriisopropoxysilane using copper catalysis
1Organisch-Chemisches Institut, Westfälische Wilhelms-Universität, Corrensstrasse 40, 48149 Münster, Germany.
Abstract:
The first catalytic desymmetrization in the field of allylsilane chemistry is presented. Desymmetrization of cyclohexadienyltriisopropoxysilane is achieved using coppper catalysis. High diastereo- and enantioselectivities are obtained, and the product dienes are highly valuable building blocks for natural product synthesis.
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