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[Primary pediatric central nervous system tumors statistic: study of 763 cases in a single institution]
Rong Zhang1, Wen-qian Shen, Liang-fu Zhou
1Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.
Insights
This study analyzed 763 pediatric central nervous system tumors, finding astrocytic tumors and craniopharyngioma were most common. Pediatric brain tumor epidemiology shows unique characteristics requiring specialized care.
Area of Science:
- Pediatric Oncology
- Neuro-oncology
- Epidemiology
Context:
- Retrospective analysis of 763 pediatric patients under 18 with primary central nervous system tumors.
- Data collected over 10 years from Huashan Hospital, a major neurological center in Southern China.
- Focus on epidemiological characteristics of pediatric central nervous system tumors.
Purpose:
- To investigate the epidemiology of primary pediatric central nervous system tumors.
- To identify the most common types and locations of these tumors in children.
- To highlight the unique aspects of pediatric central nervous system tumor epidemiology.
Summary:
- The study included 763 pediatric patients, with a mean age of 12.68 years and a male to female ratio of 1.56:1.
- Intracranial tumors (93.4%) were more common than spinal tumors (6.6%), with supratentorial locations (62.4%) predominating.
- The most frequent tumor types were astrocytic tumors (25.7%), craniopharyngioma (12.8%), medulloblastoma (9.3%), germ cell tumors (8.9%), and pituitary adenoma (7.5%).
Impact:
- Provides representative epidemiological data for pediatric central nervous system tumors in Southern China.
- Emphasizes the specialized nature of pediatric central nervous system tumors.
- Underscores the importance of tailored treatment strategies considering children's specific characteristics.
Objective:
To investigate the epidemiology of primary pediatric central nervous system tumors.
Methods:
The clinical data of 763 pediatric patients aged under 18 diagnosed as with primary central nervous system tumors in the past 10 years in Huashan Hospital were analyzed retrospectively.
Results:
The mean age was 12.68 and the male to female ratio was 1.56:1. Among the tumors intracranial tumors accounted for 93.4% (713/763), whereas spinal tumors accounted for 6.6% (50/763). 476 of the 763 tumors (62.4%) were supratentorial, including pineal-quadrigeminal tumors, which was predominant to infratentorial tumors (30.5%, 233/763). 688 of the 763 patients had pathological diagnosis. The most common 5 categories of tumors were: astrocytic tumors (25.7%, 177/688), craniopharyngioma (12.8%, 88/688), medulloblastoma (9.3%, 64/688), germ cell tumors (8.9%, 61/688), and pituitary adenoma (7.5%, 52/688).
Conclusion:
As the main neurological medical center in the southern part of China, the statistics of Huashan Hospital can be representative. The epidemiology of pediatric central nervous system tumors has its own specialty. Therefore, it is crucial to deal with primary pediatric central nervous system tumors according to children's characteristics.
