Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Forced Transdifferentiation01:28

Forced Transdifferentiation

Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial transdifferentiation occurs...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>Chlorella vulgaris</i> lipid extraction side-stream enhances growth and protein enrichment in novel food <i>Lemna minor</i> (duckweed).

Frontiers in nutrition·2026
Same author

Mixotrophic Cultivation of <i>Limnospira</i> (<i>Spirulina</i>) <i>platensis</i> Using Early-Stage Fig Processing Wastewater: Effects on Biomass Composition, Antioxidants and Phycocyanin.

Marine drugs·2026
Same author

β-cyclodextrin and succinic acid-driven metabolic enhancement of lipid, phycobiliprotein, and exopolysaccharide production in Porphyridium purpureum.

Bioprocess and biosystems engineering·2026
Same author

A novel culture flask for clinostat-based simulation of extraterrestrial gravities.

Frontiers in cell and developmental biology·2026
Same author

Correction to: Singular adaptations in the carbon assimilation mechanism of the polyextremophile cyanobacterium Chroococcidiopsis thermalis.

Photosynthesis research·2026
Same author

Superfood potential of Chlorella vulgaris: productivity and antioxidant boost under simulated moon and microgravity conditions.

NPJ microgravity·2025

Related Experiment Video

Updated: Jul 15, 2026

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes
10:48

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes

Published on: April 12, 2015

A novel simulation model for stem cells differentiation.

Massimo Pisu1, Alessandro Concas, Giacomo Cao

  • 1CRS4 (Center for Advanced Studies, Research and Development in Sardinia), Parco Scientifico e Tecnologico POLARIS, Edificio 1, 09010 Pula, Cagliari, Italy.

Journal of Biotechnology
|April 27, 2007
PubMed
Summary

A new mathematical model simulates mesenchymal stem cells (MSCs) differentiation. This model accurately predicts cell behavior in vitro and in vivo, aiding regenerative medicine and disease research.

More Related Videos

A Live-cell Image-Based Machine Learning Strategy to Monitor Pluripotent Stem Cell Differentiation
11:38

A Live-cell Image-Based Machine Learning Strategy to Monitor Pluripotent Stem Cell Differentiation

Published on: October 4, 2024

Efficient Neural Differentiation using Single-Cell Culture of Human Embryonic Stem Cells
11:17

Efficient Neural Differentiation using Single-Cell Culture of Human Embryonic Stem Cells

Published on: January 18, 2020

Related Experiment Videos

Last Updated: Jul 15, 2026

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes
10:48

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes

Published on: April 12, 2015

A Live-cell Image-Based Machine Learning Strategy to Monitor Pluripotent Stem Cell Differentiation
11:38

A Live-cell Image-Based Machine Learning Strategy to Monitor Pluripotent Stem Cell Differentiation

Published on: October 4, 2024

Efficient Neural Differentiation using Single-Cell Culture of Human Embryonic Stem Cells
11:17

Efficient Neural Differentiation using Single-Cell Culture of Human Embryonic Stem Cells

Published on: January 18, 2020

Area of Science:

  • Biomedical Engineering
  • Mathematical Biology
  • Cell Biology

Background:

  • Mesenchymal stem cells (MSCs) are crucial for tissue repair and regeneration.
  • Understanding MSC differentiation is key to developing effective cell-based therapies.
  • Existing models often lack the comprehensive scope to capture complex differentiation dynamics.

Purpose of the Study:

  • To develop a novel, generalizable mathematical model for simulating MSC differentiation.
  • To couple cell population dynamics with biochemical factors governing differentiation.
  • To validate the model against experimental data and assess its predictive power.

Main Methods:

  • A mass-structured population balance model was developed.
  • The model incorporates material balances for extracellular matrix, growth factors, and nutrients.
  • It describes cell growth, proliferation, and differentiation processes.

Main Results:

  • The model successfully simulated MSC differentiation into chondrocytes, matching experimental data for DNA and glycosaminoglycan content.
  • It accurately predicted MSC differentiation during in vivo fracture healing into chondrocytes and osteoblasts.
  • Sensitivity analysis identified key parameters influencing differentiation pathways.

Conclusions:

  • The proposed mathematical model provides a robust framework for simulating generic cell differentiation.
  • It demonstrates significant predictive capability for both in vitro and in vivo scenarios.
  • The model can be extended to study various pathologies involving MSCs and offers insights into therapeutic strategies.