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Related Experiment Videos

Is stress a trigger factor for migraine?

G G Schoonman1, D J Evers, B E Ballieux

  • 1Department of Neurology (K5-Q), Leiden University Medical Centre, P.O. Box 9600, 2300 RC Leiden, The Netherlands. g.g.schoonman@lumc.nl

Psychoneuroendocrinology
|April 27, 2007
PubMed
Summary
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Migraine patients who perceive stress before an attack show increased subjective stress but no objective biological stress markers. This study found no consistent biological evidence linking stress to migraine onset in most patients.

Area of Science:

  • Neurology
  • Psychophysiology
  • Migraine Research

Background:

  • Mental stress is a commonly suspected migraine trigger.
  • Experimental evidence directly linking stress to migraine onset is limited.

Purpose of the Study:

  • To investigate the temporal relationship between stress indicators and migraine attacks.
  • To differentiate between subjective and objective stress responses preceding migraine.

Main Methods:

  • Prospective ambulatory study of 17 migraine patients.
  • Assessed perceived stress and biological stress markers (saliva cortisol, heart rate variability) for 4 days before attacks.
  • Analyzed subgroups based on perceived stress triggers.

Main Results:

Related Experiment Videos

  • No significant group-wide changes in perceived stress or objective stress markers before attacks.
  • Stress-sensitive patients reported increased perceived stress but not objective stress changes.
  • Stress-sensitive patients had higher baseline worry and perceived stress scores.

Conclusions:

  • Migraine patients may perceive increased stress before attacks, particularly those sensitive to stress.
  • No objective biological evidence of a stress response was detected before or during migraine attacks in this study.