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Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses
Published on: April 4, 2019
[Simultaneous outbreaks of rotavirus and respiratory syncytial virus in Paris: a 12-year survey]
J-B Armengaud1, M J El Hajje, F Moulin
1Service de pédiatrie générale et laboratoire d' épidémiologie clinique, hôpital Saint-Vincent-de-Paul, 82, avenue Denfert-Rochereau, 75014 Paris, France.
Insights
Respiratory syncytial virus (RSV) and rotavirus outbreaks in Paris pediatric patients consistently peaked together in winter months over a 12-year period. This simultaneous seasonality impacts hospital capacity and infection control.
Area of Science:
- Pediatric Infectious Diseases
- Epidemiology
- Virology
Context:
- Hospitalized pediatric patients in the Paris area.
- A 12-year retrospective study (1993-2004).
Purpose:
- To investigate the temporal coincidence of Respiratory Syncytial Virus (RSV) and rotavirus epidemic peaks.
- To analyze the impact of simultaneous viral seasonality on pediatric hospitalizations.
Summary:
- Analysis of 3,496 rotavirus and 3,507 RSV positive samples.
- Observed consistent epidemic peak coincidence for both viruses during winter months (November, December, January) over 12 years.
Impact:
- The synchronized winter outbreaks of RSV and rotavirus in Paris contribute to pediatric unit overcrowding.
- This overlap increases the risk of nosocomial infections within healthcare settings.
Objective:
The authors had for aim to study the coincidence of RSV and rotavirus epidemic peaks in pediatric patients hospitalized in the Paris area.
Methodology:
A retrospective hospital-based monocentric cohort study was made over a 12-year period (1993-2004). Clinical and laboratory findings were prospectively collected on admission.
Results:
Three thousand and four hundred ninety-six stool samples were positive for rotavirus; 3,507 nasopharyngeal aspirates were positive for RSV. The coincidence of epidemic peaks for both viruses in November, December, and January was observed during the 12 years of the study.
Conclusion:
The exact coincidence of winter outbreaks of RSV and rotavirus is a characteristic of the Paris area. It contributes to increase overcrowding in pediatric units and nosocomial infections.
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