Related Experiment Video
Updated: Jul 12, 2026
10:38
Deciphering and Imaging Pathogenesis and Cording of Mycobacterium abscessus in Zebrafish Embryos
Published on: September 9, 2015
Pulmonary Mycobacterium avium complex infection: association with NRAMP1 polymorphisms
G Tanaka1, J Shojima, I Matsushita
1Dept of Respiratory Diseases, Research Institute, International Medical Center of Japan, 1-21-1 Toyama, Tokyo 162-8655, Japan.
The European Respiratory Journal
|April 27, 2007
Summary
Genetic variations in the human natural resistance-associated macrophage protein 1 (NRAMP1) gene may influence susceptibility to pulmonary Mycobacterium avium complex (MAC) infection, particularly in individuals without comorbidities. This finding offers insights into the genetic factors underlying MAC disease.
Area of Science:
- Genetics
- Infectious Diseases
- Immunology
Background:
- Pulmonary Mycobacterium avium complex (MAC) infection affects nonimmunocompromised individuals.
- Understanding genetic risk factors is crucial for elucidating MAC pathogenesis.
Purpose of the Study:
- To identify genetic variations associated with nonimmunocompromised pulmonary MAC infection.
- To investigate the role of specific gene polymorphisms in MAC susceptibility.
Main Methods:
- Genotyping of four NRAMP1 gene polymorphisms (5'(GT)n, 469+14 G/C, D543N, 3'TGTG) using PCR.
- Evaluation of vitamin D receptor and mannose binding lectin gene polymorphisms.
- Analysis of epidemiological data in 111 pulmonary MAC patients and controls.
Main Results:
- Females showed higher susceptibility to MAC infection, primarily affecting the right middle lobe or lingula.
- Heterozygotes with minor alleles of NRAMP1 D543N and TGTG polymorphisms were less frequent in MAC cases than controls.
- This genetic association was significant in patients without comorbidity.
Conclusions:
- The human natural resistance-associated macrophage protein 1 (NRAMP1) gene may play a role in susceptibility to pulmonary MAC infection.
- NRAMP1 gene polymorphisms, specifically D543N and TGTG, are associated with reduced risk in non-comorbid individuals.
- Further research is warranted to confirm the role of NRAMP1 in MAC pathogenesis.
Related Concept Videos
01:05Single Nucleotide Polymorphisms-SNPs
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
01:29Pulmonary Tuberculosis I
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
01:28Pulmonary Tuberculosis II
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
01:31Pulmonary Tuberculosis III
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
01:28Pulmonary Tuberculosis V
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
01:14Atypical Pneumonia
Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...