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Updated: Jul 15, 2026

Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics
08:16

Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics

Published on: July 23, 2020

[Effect of volatile inhalational anesthetics on cerebral blood volume and oxygen status in children]

L E Tsypin, G G Prokop'ev, V V Lazarev

    Anesteziologiia I Reanimatologiia
    |April 28, 2007
    PubMed

    Insights

    Halothane significantly increased cerebral blood volume in sick children during anesthesia induction compared to enflurane and sevoflurane. Regional cerebral tissue saturation remained high across all anesthetic groups.

    Area of Science:

    • Anesthesiology
    • Pediatric Critical Care
    • Neuroscience

    Background:

    • Anesthesia induction in pediatric patients requires careful monitoring of cerebral hemodynamics.
    • Volatile anesthetics can impact cerebral blood volume and oxygenation, necessitating evaluation in vulnerable populations.
    • Understanding these effects is crucial for optimizing anesthetic management in sick children.

    Purpose of the Study:

    • To compare the effects of halothane, enflurane, and sevoflurane on cerebral blood volume during anesthesia induction in children.
    • To assess the impact of these anesthetics on regional cerebral tissue oxygenation (rSO2) in pediatric patients.

    Main Methods:

    • A study involving 92 children undergoing anesthesia induction.
    • Three groups received different anesthetic agents: stepwise halothane, stepwise enflurane, or rapid inhalation sevoflurane.
    • Cerebral oximetry utilizing near-infrared spectroscopy (NIRS) was employed to measure hemoglobin derivatives and rSO2.

    Main Results:

    • Halothane increased cerebral blood volume by 20.5%, significantly more than enflurane (8.8%) and sevoflurane (9.0%).
    • Regional cerebral tissue saturation (rSO2) remained elevated above baseline by 3-5% in all anesthetic groups.
    • All tested volatile anesthetics maintained adequate cerebral oxygenation during induction.

    Conclusions:

    • Halothane causes a more pronounced increase in cerebral blood volume during induction compared to enflurane and sevoflurane in children.
    • Sevoflurane and enflurane appear to be associated with less cerebral blood volume expansion.
    • Despite variations in cerebral blood volume, all evaluated anesthetics maintained satisfactory cerebral oxygenation in this pediatric cohort.

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