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Leuconostoc species-associated endocarditis.

Jessica A Starr1

  • 1Auburn University Harrison School of Pharmacy, Birmingham, Alabama, USA. jas0003@auburn.edu

Pharmacotherapy
|April 28, 2007
PubMed
Summary

Leuconostoc bacteria, typically nonpathogenic, can cause serious infections like endocarditis. This case highlights a rare instance of Leuconostoc endocarditis sensitive to vancomycin, successfully treated with standard antibiotics.

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Area of Science:

  • Clinical Microbiology
  • Infectious Diseases
  • Bacteriology

Background:

  • Leuconostoc species, Gram-positive cocci in the Streptococcaceae family, were historically considered nonpathogenic.
  • Recent reports indicate increasing clinical significance and potential pathogenicity of Leuconostoc species.
  • These bacteria often exhibit high-level vancomycin resistance, complicating treatment strategies.

Observation:

  • A 55-year-old male patient presented with endocarditis.
  • The causative agent was identified as Leuconostoc species.
  • This specific strain demonstrated an unusual sensitivity to vancomycin.

Findings:

  • The patient underwent aortic valve replacement surgery.
  • Treatment involved penicillin G and gentamicin, standard antibiotics for certain bacterial infections.
  • The patient experienced a full recovery without further complications.

Implications:

  • This case challenges the general assumption of vancomycin resistance in Leuconostoc species.
  • It underscores the importance of susceptibility testing for guiding antimicrobial therapy in rare infections.
  • Highlights the potential for successful treatment of Leuconostoc endocarditis with conventional antimicrobial regimens.

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