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Neoadjuvant use of endocrine therapy in breast cancer

E Jane Macaskill1, J Michael Dixon

  • 1Edinburgh Breast Unit, Western General Hospital, Edinburgh EH4 2XU, United Kingdom.

The Breast Journal
|April 28, 2007
PubMed

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Endocrine Signaling

Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.