Related Experiment Video
Updated: Jul 15, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
Published on: November 4, 2025
Preoperative anthropometric analysis of the cleft child's face: a comparison between groups
1Guy's, King's and St. Thomas' School of Medicine, King's College London, London SE1 9RT, UK.
Insights
This study analyzed facial morphology in infants with cleft lip and palate before surgery. Infants with cleft lip showed a wider nasal base and altered upper lip dimensions compared to controls.
Area of Science:
- Craniofacial morphology
- Pediatric plastic surgery
- Anthropometry
Background:
- Cleft lip and palate deformities significantly impact facial development.
- Pre-operative assessment of facial morphology is crucial for surgical planning.
- Understanding baseline facial differences aids in defining the cleft syndrome.
Purpose of the Study:
- To identify and assess differences in facial morphology of infants with clefts before corrective surgery.
- To compare facial measurements between cleft and non-cleft infant groups.
- To propose a model illustrating facial anatomy in cleft and non-cleft individuals.
Main Methods:
- Anthropometric measurements of standard facial landmarks were taken from pre-operative plaster casts.
- Infants up to eleven months old, with and without cleft deformities, were included.
- Comparative analysis was performed between control and cleft groups.
Main Results:
- No significant differences were observed in periorbital and mid-face measurements.
- Infants with cleft lip exhibited a wider nasal base on both cleft and non-cleft sides.
- Upper lip measurements revealed shortening, lateral deviation, and superolateral rotation in the cleft group.
Conclusions:
- Facial morphology in infants with cleft lip and palate presents specific pre-operative alterations, particularly in the nasal base and upper lip.
- A diagrammatic model is proposed to represent these anatomical differences.
- Further research is recommended to build a comprehensive database for potential redefinition of the cleft syndrome based on anthropometric data.
Abstract:
This study examines the facial surfaces of different groups of cleft babies aged up to eleven months, prior to any corrective surgery, with the aim of identifying and assessing differences in their facial morphology. Measurements of standard anthropometric landmarks were made on plaster casts taken pre-operatively of the faces of babies presenting for surgical correction of lip and palate deformities. Periorbital and mid face measurements show no difference between control and cleft groups. The nasal base is shown to be wider in infants with cleft lip on both cleft and non-cleft sides. Upper lip measurements indicate shortening, lateral deviation and superolateral rotation. A diagrammatic model is proposed to illustrate facial anatomy in control and cleft individuals. Modifications to the technique are proposed. Further study in this field is suggested, in order to produce a comprehensive database of facial morphological changes in the cleft and non-cleft populations both pre-operatively and over time, with a view to producing a potential redefinition of the cleft syndrome based on anthropometric principles.

