Related Experiment Video
Updated: Jul 15, 2026

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice
Published on: April 27, 2014
Current diagnosis of interstitial cystitis: an evolving paradigm
Robert J Evans1, Grannum R Sant
1Department of Surgery, Moses Cone Health System, Greensboro, North Carolina, USA. revans@tucpa.com
Diagnosing interstitial cystitis (IC) is evolving. Clinicians can now diagnose IC earlier using updated guidelines focusing on patient history and physical exams, making other tests optional.
Area of Science:
- Urology
- Nephrology
Background:
- Interstitial cystitis (IC) diagnosis has traditionally followed a rigid paradigm.
- Advances in understanding IC prevalence and presentation enable earlier detection.
Purpose of the Study:
- To present an updated diagnostic paradigm for interstitial cystitis.
- To incorporate recent clinical data and consensus discussions.
Main Methods:
- Review of clinical data and consensus discussions from international symposia (ICICJ, NIDDK/ICA).
- Emphasis on patient history (urgency, frequency, pain) and physical examination.
- Exclusion of bacterial infection and malignancy as primary causes.
Main Results:
- The traditional diagnostic steps are no longer mandatory for IC diagnosis.
- A diagnosis can be established based on history and physical exam alone.
- Symptom questionnaires aid in diagnosis, while cystoscopy and urodynamics are optional.
Conclusions:
- The diagnostic approach for IC has evolved towards a more streamlined process.
- Early diagnosis of IC is facilitated by focusing on key clinical indicators.
- Evidence-based medicine supports a diagnosis of IC without routine use of cystoscopy or urodynamics.
Related Concept Videos
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
Acute Pyelonephritis II: Diagnostic Studies and Management
Urinary Tract Infection II: Pathophysiology
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
Imaging Studies VI: Voiding Cystourethrography and Cystography
Urinary Tract Infection IV: Nursing Management
