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Identification of a new HLA-B allele (B*1576) by haplotype specific extraction

Johannes Dapprich1, Klaus Witter, Harrison W Gabel

  • 1Generation Biotech, Lawrenceville, New Jersey 08648, USA. jdapprich@generationbiotech.com

Human Immunology
|April 28, 2007
PubMed

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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