Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Synthetic Biology

Synthetic Biology

Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...

Biosynthesis in Bacteria

Biosynthesis in Bacteria

Biosynthesis in bacteria is a fundamental anabolic process that generates essential macromolecules, including proteins, nucleic acids, lipids, and polysaccharides. These macromolecules are critical for cellular growth, replication, and function. The process is tightly regulated and energetically linked to catabolic pathways to ensure optimal resource utilization.Biosynthetic pathways begin with precursor metabolites such as pyruvate, acetyl-CoA, and glucose-6-phosphate derived from glycolysis,...

Introduction to Enzymes

Introduction to Enzymes

The use of enzymes by humans dates to 7000 BCE. Humans first used enzymes to ferment sugars and produce alcohol without knowing that this was an enzyme-catalyzed reaction. Wilhelm Kuhne coined the term 'enzyme' in 1877 from the Greek words ‘en’ meaning ‘in’ or ‘within’ and ‘zyme’ meaning ‘yeast.’
Most enzymes are proteins that speed up biochemical reactions without being consumed. Enzymes contain one or more active sites that bind the substrates and convert them into products. Many enzymes also...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Mycobacterial cyt-<i>bc</i><sub>1</sub><i>:aac<sub>3</sub></i> Oxidase as a Drug Target: Activities of Arylvinylpiperazine Amides and Aminoquinazolines against <i>Mycobacterium ulcerans</i>.

Journal of medicinal chemistry·2026

Same author

An atlas of microtubule lattice parameters regulated through ligand binding to the microtubule-stabilizing sites.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same author

Illuminating chromaffin granules: compartmentalization of endocannabinoids in bovine adrenal glands supports role in hormone modulation.

Biochemical pharmacology·2026

Same author

Studies toward the Total Synthesis of Griseoviridin.

Organic letters·2026

Same author

Synthesis and Early Assessment of Epothilone-Derived Fluorescent Probes for Microtubule Imaging.

ChemMedChem·2026

Same author

Optimizing the Antibiotic Potency and Metabolic Stability of Pyridomycin Using a Semisynthetic Approach.

Journal of medicinal chemistry·2026

Search research articles

Related Experiment Video

Updated: Jul 15, 2026

Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials

Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials

Published on: March 9, 2017

Chemical tools from biology-oriented synthesis.

Karl-Heinz Altmann¹

¹Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH) Zürich, HCI H 405, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland. karl-heinz.altmann@pharma.ethz.ch

Chemistry & Biology

|April 28, 2007

Summary

Researchers created a diverse library of chiral lactones using solid-phase synthesis. This collection yielded potent modulators for cell cycle control and viral entry, demonstrating high efficacy in phenotypic screening.

More Related Videos

Rapid Characterization of Genetic Parts with Cell-Free Systems

Rapid Characterization of Genetic Parts with Cell-Free Systems

Published on: August 30, 2021

A Fluorescence-based Protocol for Preliminary Screening of Protein Synthesis Inhibitors from Natural Sources

A Fluorescence-based Protocol for Preliminary Screening of Protein Synthesis Inhibitors from Natural Sources

Published on: January 27, 2026

Related Experiment Videos

Last Updated: Jul 15, 2026

Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials

Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials

Published on: March 9, 2017

Rapid Characterization of Genetic Parts with Cell-Free Systems

Rapid Characterization of Genetic Parts with Cell-Free Systems

Published on: August 30, 2021

A Fluorescence-based Protocol for Preliminary Screening of Protein Synthesis Inhibitors from Natural Sources

A Fluorescence-based Protocol for Preliminary Screening of Protein Synthesis Inhibitors from Natural Sources

Published on: January 27, 2026

Area of Science:

Medicinal Chemistry
Organic Synthesis
Drug Discovery

Background:

Development of novel therapeutic agents requires access to diverse chemical scaffolds.
Chiral natural products offer unique structural motifs for drug discovery.
Solid-phase synthesis enables efficient generation of compound libraries.

Discussion:

Lessmann et al. synthesized a library of alpha,beta-unsaturated delta-lactones derived from natural products.
Stereoselective synthesis on a solid support facilitated library generation.
Phenotypic screening identified compounds with significant biological activity.

Key Insights:

The study presents a novel, stereochemically defined library of lactones.
High hit rates were achieved in phenotypic screening.
Identified modulators target cell cycle progression and viral cell entry.

Outlook:

This library serves as a valuable resource for identifying new drug leads.
Further optimization of identified modulators could lead to therapeutic candidates.
The synthetic methodology is applicable to other natural product-derived scaffolds.