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Related Concept Videos

Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
Catenins01:23

Catenins

Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the adherens...
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However, invadopodia can...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...

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Related Experiment Video

Updated: Jul 15, 2026

Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model
06:32

Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model

Published on: November 4, 2022

When prostate cancer meets bone: control by wnts.

Katayoon H Emami1, Eva Corey

  • 1CGEN Discovery Inc., 600 Broadway STE580, Seattle, WA 98122, USA.

Cancer Letters
|April 28, 2007
PubMed
Summary

Wnt signaling promotes prostate cancer (CaP) cell growth in bone, leading to osteoblastic bone metastases. Understanding this pathway is key to treating advanced prostate cancer and its bone complications.

Area of Science:

  • Oncology
  • Bone Biology
  • Cell Signaling

Background:

  • Advanced prostate cancer (CaP) frequently metastasizes to bone, causing osteoblastic lesions.
  • The mechanisms by which CaP cells establish in bone and induce lesions are not fully understood.
  • Wnt signaling, crucial in development and cancer, is implicated in CaP bone metastases.

Purpose of the Study:

  • To review the role of Wnt signaling in prostate cancer.
  • To examine Wnt signaling's function in bone development and homeostasis.
  • To elucidate the involvement of Wnt signaling in the establishment and progression of CaP bone metastases.

Main Methods:

  • Literature review of studies on Wnt signaling, prostate cancer, and bone metastasis.
  • Analysis of research linking CaP-expressed Wnt factors to bone microenvironment interactions.

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Pre-clinical Orthotopic Murine Model of Human Prostate Cancer
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Pre-clinical Orthotopic Murine Model of Human Prostate Cancer

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An Orthotopic Murine Model of Human Prostate Cancer Metastasis
06:48

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

Related Experiment Videos

Last Updated: Jul 15, 2026

Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model
06:32

Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model

Published on: November 4, 2022

Pre-clinical Orthotopic Murine Model of Human Prostate Cancer
07:01

Pre-clinical Orthotopic Murine Model of Human Prostate Cancer

Published on: August 29, 2016

An Orthotopic Murine Model of Human Prostate Cancer Metastasis
06:48

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

  • Synthesis of findings on Wnt pathway regulation of osteoblast and osteoclast differentiation in the context of CaP.

    • Main Results:

    • Prostate cancer cells exhibit heightened Wnt signaling compared to normal prostate epithelium.
    • Wnt signaling factors secreted by CaP cells can promote CaP cell colonization in bone.
    • Wnt signaling plays a critical role in regulating bone cells (osteoblasts and osteoclasts), influencing lesion formation.

    Conclusions:

    • Wnt signaling is a key pathway in prostate cancer progression and the development of bone metastases.
    • Targeting Wnt signaling pathways may offer therapeutic strategies for advanced prostate cancer with bone involvement.
    • Further research into CaP-Wnt-bone interactions is essential for developing effective treatments.