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A key role for CCR7 in establishing central and peripheral tolerance
1Institute of Immunology, Hannover Medical School, 30625 Hannover, Germany.
Trends in Immunology
|April 28, 2007
Summary
The CC-chemokine receptor (CCR)7 guides immune cells to lymph nodes for primary responses. Recent findings reveal CCR7 is also vital for establishing immunological tolerance, impacting both immunity and tolerance.
Area of Science:
- Immunology
- Cell Biology
Background:
- CC-chemokine receptor (CCR)7 is recognized for its role in naive T cell and dendritic cell homing to lymph nodes.
- Initially considered key for primary immune responses, CCR7's function is now understood to be broader.
Purpose of the Study:
- To review recent advances in understanding the multifaceted roles of CCR7.
- To highlight CCR7's involvement in both the induction and maintenance of immunological tolerance.
Main Methods:
- Literature review of recent studies on CCR7 function.
- Analysis of data concerning immune cell migration and tolerance induction.
Main Results:
- CCR7 directs immune cell migration essential for initiating adaptive immunity.
- Emerging evidence shows CCR7 is critical for establishing central and peripheral immunological tolerance.
- CCR7's role extends beyond immunity to encompass tolerance mechanisms.
Conclusions:
- CCR7 is a pivotal regulator in immune responses and immunological tolerance.
- Understanding CCR7's diverse functions is crucial for developing new therapeutic strategies.
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