Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Risk screening for spontaneous preterm labour.

Khalid S Khan1, Honest Honest

  • 1Department of Obstetrics and Gynaecology, Birmingham Women's Hospital, University of Birmingham, UK. k.s.khan@bham.ac.uk

Best Practice & Research. Clinical Obstetrics & Gynaecology
|April 28, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

E-health intervention in pregnant women exposed to intimate partner violence (eIPV): Results of a pilot randomised controlled trial.

Contemporary clinical trials communications·2026
Same author

Response: Letter to the Editor regarding International multi-stakeholder consensus statement on post-publication integrity issues in randomized clinical trials by Cairo Consensus Group.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics·2026
Same author

Obstetric violence prevalence and risk factors: an umbrella review.

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology·2025
Same author

Effect of Primary Surgery on Health-Related Quality of Life in Metastatic Breast Cancer: A Systematic Review of RCT's.

The American surgeon·2025
Same author

Editorial: The integrity of randomized clinical trials: consensus statements from Hong Kong to Cairo.

Frontiers in research metrics and analytics·2025
Same author

Quality of life measurement tools for heavy menstrual bleeding: A systematic review and critical appraisal.

Sexual & reproductive healthcare : official journal of the Swedish Association of Midwives·2025
Same journal

A risk-based classification of late-onset fetal growth disorders according to intrapartum fetal compromise.

Best practice & research. Clinical obstetrics & gynaecology·2026
Same journal

The Cardiac-Fetal-Placental Unit: links between umbilical venous flow and maternal hemodynamics in fetal growth restriction.

Best practice & research. Clinical obstetrics & gynaecology·2026
Same journal

Psychosocial interventions for women who are pregnant following a previous reproductive loss: A scoping review.

Best practice & research. Clinical obstetrics & gynaecology·2026
Same journal

Controversies in fetal therapy.

Best practice & research. Clinical obstetrics & gynaecology·2026
Same journal

Alloimmunisation in pregnancy: current management and future perspectives.

Best practice & research. Clinical obstetrics & gynaecology·2026
Same journal

Consensus in prenatal management of Hemolytic disease of the fetus and newborn.

Best practice & research. Clinical obstetrics & gynaecology·2026
See all related articles

Screening for spontaneous preterm birth can guide targeted interventions. Using a previous history of preterm birth with progesterone therapy significantly reduces the number needed to treat for prevention.

Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Public Health

Background:

  • Spontaneous preterm birth before 34 weeks' gestation poses significant risks to child, mother, and society.
  • Current understanding of preterm birth mechanisms is limited, hindering effective prediction and prevention strategies.
  • A lack of randomized controlled trials exists for screening programs aimed at preventing preterm birth complications.

Purpose of the Study:

  • To develop a generic framework for integrating screening information with therapeutic effects in antenatal care.
  • To evaluate the test-treatment combination of previous preterm birth history and progestational agents for prevention.
  • To provide a decision-making framework for screening and prevention of spontaneous preterm birth.

Main Methods:

Related Experiment Videos

  • A decision-making framework was constructed using evidence for post-test probabilities and therapeutic effectiveness.
  • Integration of screening data and treatment efficacy was performed to estimate the impact of interventions.
  • Numbers needed to treat (NNTs) were calculated to quantify the effectiveness of the test-treatment combination.

Main Results:

  • The NNT to prevent one case of spontaneous preterm birth before 34 weeks' gestation using progesterone was 7 for women with a previous history.
  • The NNT was 41 for women without a previous history of preterm birth.
  • When previous history was not used to guide decisions, the NNT was 28.

Conclusions:

  • The proposed framework effectively integrates screening and treatment data to guide decisions in antenatal care.
  • Previous history of preterm birth is a crucial factor in optimizing the use of progesterone for prevention.
  • This approach enhances the explicitness and potential effectiveness of screening and prevention programs for spontaneous preterm birth.