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Published on: August 1, 2018
Synthesis, characterization and cytolytic activity of alpha-helical amphiphilic peptide nanostructures containing
Pierre-Luc Boudreault1, Normand Voyer
1Département de chimie and Centre de recherche sur la fonction, la structure et l'ingénierie des protéines, Faculté des sciences et génie, Université Laval, Québec, CanadaG1K 7P4.
Abstract:
Many natural alpha-helical amphiphilic peptides are known to have lytic activity toward different cells. Herein, we describe the synthesis and the characterization of synthetic alpha-helical amphiphilic peptide nanostructures containing crown ethers, as well as the modulation of their cytolytic activity by adding different acidic dipeptide chains at the N- or C-terminus.

