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Related Concept Videos

Obsessive-Compulsive Disorder01:28

Obsessive-Compulsive Disorder

Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...
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Related Experiment Video

Updated: Jul 15, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
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Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

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Hippocampal shape deformity analysis in obsessive-compulsive disorder.

Soon Beom Hong1, Yong-Wook Shin, Sun Hyung Kim

  • 1Department of Psychiatry, Seoul National University College of Medicine, SNUMRC, 28 Yongon-dong, Chongno-gu, 110-744 Seoul, Korea. kwonjs@plaza.snu.ac.kr

European Archives of Psychiatry and Clinical Neuroscience
|April 28, 2007
PubMed
Summary

Obsessive-compulsive disorder (OCD) may involve hippocampal abnormalities. This study found distinct bilateral hippocampal shape deformities in OCD patients, suggesting a role for this brain structure in the disorder's pathophysiology.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Neuroimaging

Background:

  • Previous research on obsessive-compulsive disorder (OCD) pathophysiology primarily identified abnormalities in the orbital prefrontal cortex and caudate nuclei.
  • Neuroimaging studies have yielded inconsistent findings regarding hippocampal abnormalities in OCD patients.

Purpose of the Study:

  • To investigate hippocampal structural abnormalities in OCD patients using advanced shape analysis techniques.
  • To resolve discordance in previous neuroimaging findings concerning the hippocampus in OCD.

Main Methods:

  • Employed shape analysis to detect local structural changes in the hippocampus.
  • Compared hippocampal shape in 22 matched pairs of OCD patients and normal control subjects.

Main Results:

  • Observed significant bilateral hippocampal shape deformity in OCD patients.
  • The most prominent characteristic was a downward displacement of the hippocampal head.

Conclusions:

  • The identified hippocampal structural alterations suggest a potential role in the pathophysiology of OCD.
  • These shape deformities may reflect developmental alterations in the neural circuitry involving the hippocampus in OCD patients.