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Application of Laser Micro-irradiation for Examination of Single and Double Strand Break Repair in Mammalian Cells
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Published on: September 5, 2017

Chromosomal damage in two X-ray irradiated cell lines: influence of cell cycle stage and irradiation temperature

D E Larsson1, S Gustavsson, R Hultborn

  • 1Department of Oncology, Göteborg University, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden.

Anticancer Research
|May 1, 2007
PubMed
Abstract

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Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
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In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
DNA Damage Can Stall the Cell Cycle02:36

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