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Updated: Jul 15, 2026
11:02
Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
Prohibitin in the pathogenesis of transitional cell bladder cancer
Ting-Feng Wu1, Hung Wu, Yi-Wen Wang
1Department of Biotechnology, Southern Taiwan University of Technology, Tainan, Taiwan, ROC.
Anticancer Research
|May 1, 2007
Summary
Prohibitin 1 (PHB) is overexpressed in bladder cancer and linked to tumor progression. Targeting PHB with agents like genistein may offer a new strategy for bladder cancer treatment and prevention.
Area of Science:
- Oncology
- Molecular Biology
- Urology
Background:
- Prohibitin 1 (PHB) is ubiquitously expressed in urothelial carcinoma cell lines.
- PHB shows a trend toward a positive relationship with tumor progression.
Purpose of the Study:
- To investigate the role of PHB in multistage bladder carcinogenesis.
- To determine if PHB can predict patient outcomes in bladder cancer.
Main Methods:
- Immunohistochemical staining was used to assess PHB expression in 167 bladder cancer cases.
- Correlation analysis was performed to relate PHB expression to clinical parameters and patient survival.
- In vitro experiments evaluated the effect of genistein and justicidin A on PHB expression.
Main Results:
- PHB was overexpressed in 84.4% of bladder cancer cases.
- PHB overexpression correlated with met receptor overexpression and multiple tumors.
- Multiple tumors, muscle invasion, and met overexpression were independent predictors of patient survival.
Conclusions:
- PHB is activated early in bladder cancer development.
- PHB may synergize with met in bladder cancer progression.
- Targeting PHB with natural agents like genistein presents a potential therapeutic strategy for bladder cancer.
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