Related Experiment Video
Updated: Jul 15, 2026
Validated Immunochemical Assay for Comprehensive Determination of the Human Epidermal Growth Factor Receptor 2 Released from and Bound to Cells
Published on: May 9, 2025
The prognostic significance of human epidermal growth factor receptor correlations in squamous cell cervical
I Fuchs1, N Vorsteher, H Bühler
1Department of Gynecology, Charité C. Virchow, Augustenburger Platz 1, 13353 Berlin, Germany. ilka.fuchs@charite.de
Unlabelled:
The aim of this study was to investigate the expression and prognostic influence of HER1 (EGFR), HER2 (c-erb-B2), HER3 (c-erb-B3) and HER4 (cerb-B4) in squamous cell cervical carcinomas (SCC) and the importance of receptor correlations.
Patients And Methods:
78 SCC were stained immunohistochemically for HER1-HER4. HER2 gene amplification was determined using fluorescence in situ hybridization (FISH). Parametric correlations were performed between the four receptors and tumor characteristics. Overall survival was evaluated by uni- and multivariate analyses.
Results:
Overexpression was found in 63% of SCC for HER1, in 21.8% for HER2, in 74.4% for HER3 and in 79.5% for HER4. Correlations were observed between HER1 and HER4 (p = 0.019). Survival analyses revealed a significant association of HER1 overexpression with favorable outcome (p = 0.016), while overexpression of HER2 and HER3 was associated with poor prognosis (p = 0.006; p = 0.05, respectively). HER1 remained significant in multivariate analysis.
Conclusion:
These data suggest that the prognostic relevance of the different HER receptors is influenced by the balance between the various receptors, especially of HER4.
