Related Experiment Video
Updated: Jul 15, 2026

Identifying Frailty Using Point-of-Care Ultrasonography: Image Acquisition and Assessment
Published on: July 26, 2024
Frailty as a dysruption of steroid "syncrinology" in elderly man
1Dipartimento di Medicina Interna e Scienze Biomediche, Sezione di Gerontologia e Geriatria, University of Parma, Parma, Italy. giorgio.valenti@unipr.it
Abstract:
In the background of the endocrinological hypothesis of aging, frailty in man can be seen as a dysruption of syncrinology, a term with which we could define the harmonized activity of steroid hormones (DHEAS, cortisol, testosterone). Such endocrine age-related modifications might promote the activation of sarcopenia, which exerts a core position in the progression of frailty in the elderly. Consequently, the use of replacement treatment in order to delay the beginning of such steroid derangement might be a suitable strategy to improve the quality of life of man, whose life length has been significantly extended.
Related Concept Videos
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Pharmacodynamics in Geriatric Patients: Effects of Age
The Effect of Aging on Tissues
Drug Dosing: Geriatric Patients
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
