Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Dec 15, 2025

Long-Term Continuous Measurement of Renal Blood Flow in Conscious Rats
05:09

Long-Term Continuous Measurement of Renal Blood Flow in Conscious Rats

Published on: February 8, 2022

2.9K

Renal function and vasopressin during marathon running.

Joseph G Verbalis1

  • 1Department of Medicine, Georgetown University, Washington, DC 20007, USA. verbalis@georgetown.edu

Sports Medicine (Auckland, N.Z.)
|May 1, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hyponatremia: Pathophysiology of different etiologies.

Best practice & research. Clinical endocrinology & metabolism·2026
Same author

Blunted arginine vasopressin secretion in individuals experiencing a major depressive episode with comorbid post-traumatic stress disorder: Results from an exploratory study using copeptin as a surrogate marker.

Journal of neuroendocrinology·2026
Same author

The Concise Guide to PHARMACOLOGY 2025/26: G protein-coupled receptors.

British journal of pharmacology·2025
Same author

Treatment of hyponatremia: comprehension and best clinical practice.

Clinical and experimental nephrology·2025
Same author

Pathophysiology, symptoms, outcomes, and evaluation of hyponatremia: comprehension and best clinical practice.

Clinical and experimental nephrology·2025
Same author

Approach to the Patient With Suspected Hypotonic Polyuria.

The Journal of clinical endocrinology and metabolism·2024
Same journal

Re-establishing Confidence in Confidence Intervals: An Evaluation of Recent Practices in Sport Injury Epidemiology.

Sports medicine (Auckland, N.Z.)·2026
Same journal

Reliable Change of Blood-Based Biomarkers Following Acute Sport-Related Concussion: A CARE Consortium Study.

Sports medicine (Auckland, N.Z.)·2026
Same journal

Polygenic Score Identifies Athletes at Increased Risk for Slower Recovery After Sport-Related Concussion: A Concussion Assessment, Research, and Education (CARE) Consortium Study.

Sports medicine (Auckland, N.Z.)·2026
Same journal

Precision Exercise for Breast Cancer-Related Outcomes: Towards Personalised Training Based on Tumour, Treatment and Patient Characteristics.

Sports medicine (Auckland, N.Z.)·2026
Same journal

Factors Influencing Consultant Knee Surgeons' Decision Making in Anterior Cruciate Ligament (ACL) Injury Management in Athletes: An International Delphi Study.

Sports medicine (Auckland, N.Z.)·2026
Same journal

Systemic Degree of Perturbation of Plasma Markers Reveals Cumulative Biological Stress Across the Competitive Season in Professional Soccer Players.

Sports medicine (Auckland, N.Z.)·2026
See all related articles

Exercise-associated hyponatraemia (EAH) is linked to excessive fluid intake and elevated arginine vasopressin (AVP) levels during endurance activities. Individual susceptibility to EAH depends on AVP response and fluid intake management.

Area of Science:

  • Sports Medicine
  • Exercise Physiology
  • Endocrinology

Background:

  • Exercise-associated hyponatraemia (EAH) is a significant complication of prolonged endurance exercise.
  • Previously, EAH was primarily attributed to excessive fluid consumption leading to dilutional hyponatraemia.
  • However, evidence suggests that EAH is not solely caused by overhydration.

Purpose of the Study:

  • To investigate the multifactorial causes of exercise-associated hyponatraemia (EAH).
  • To explore the role of arginine vasopressin (AVP) in the pathogenesis of EAH during endurance activities.

Main Methods:

  • Review of existing data on EAH and fluid balance during prolonged exercise.
  • Analysis of the physiological responses to exercise, including fluid retention and AVP secretion.

More Related Videos

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

4.8K
Use of a Hanging-weight System for Isolated Renal Artery Occlusion
07:54

Use of a Hanging-weight System for Isolated Renal Artery Occlusion

Published on: July 19, 2011

16.4K

Related Experiment Videos

Last Updated: Dec 15, 2025

Long-Term Continuous Measurement of Renal Blood Flow in Conscious Rats
05:09

Long-Term Continuous Measurement of Renal Blood Flow in Conscious Rats

Published on: February 8, 2022

2.9K
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

4.8K
Use of a Hanging-weight System for Isolated Renal Artery Occlusion
07:54

Use of a Hanging-weight System for Isolated Renal Artery Occlusion

Published on: July 19, 2011

16.4K
  • Examination of factors influencing individual susceptibility to EAH.

    • Main Results:

    • While high fluid intake contributes to EAH, it is not the sole cause.
    • The kidney's sensitivity to arginine vasopressin (AVP) plays a crucial role.
    • Non-osmotic stimuli during exercise can elevate AVP levels, promoting water retention.

    Conclusions:

    • EAH likely results from a combination of increased fluid intake and modest elevations in plasma AVP during prolonged exercise.
    • Individual susceptibility to EAH is determined by the degree of AVP stimulation and the ability to suppress it with fluid intake.
    • Understanding these factors is key to managing and preventing this potentially life-threatening condition.