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Related Experiment Videos

Oxygen, epigenetics and stem cell fate.

Kelly Okazaki1, Emin Maltepe

  • 1University of California, Department of Cell and Tissue Biology, San Francisco, CA 94143, USA.

Regenerative Medicine
|May 1, 2007
PubMed
Summary
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Hypoxia-inducible factors and epigenetic mechanisms regulate embryonic development by controlling stem cell fate. Understanding these interactions is key to deciphering stem cell niches and progenitor self-renewal.

Area of Science:

  • Developmental Biology
  • Epigenetics
  • Stem Cell Biology

Background:

  • Embryonic development relies on coordinated environmental interactions, including oxygen levels.
  • Mammalian embryos develop in a hypoxic environment, making cellular responses to oxygen deprivation crucial.
  • Physiological factors like oxygen tension significantly impact developmental outcomes.

Purpose of the Study:

  • To review the interplay between hypoxia-inducible factors and epigenetic mechanisms in regulating embryonic development.
  • To highlight the role of hypoxia-inducible factors in integrating physiological and epigenetic signals.
  • To explore the impact of these interactions on stem cell fate and niche determination.

Main Methods:

  • Analysis of existing literature on hypoxia-inducible factors and epigenetic regulation.

Related Experiment Videos

  • Examination of the interaction between hypoxia-inducible factors and histone deacetylase (HDAC) enzymes.
  • Review of studies on embryonic and extra-embryonic stem cell populations in mice and humans.

    • Main Results:

    • Hypoxia-inducible factors physically interact with HDACs, modulating their activity.
    • This interaction is pivotal in integrating physiological oxygen sensing with epigenetic control of gene expression.
    • The interaction influences the fate of multiple embryonic and extra-embryonic stem cell populations.

    Conclusions:

    • The interaction between hypoxia-inducible factors and HDACs is a critical determinant of stem cell fate.
    • Understanding these pathways offers insights into the metabolic and molecular factors governing stem cell niches.
    • This knowledge is essential for comprehending progenitor self-renewal in an undifferentiated state.