Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sex steroids and endothelial function: translating basic science to clinical practice.

Virginia M Miller1, Sharon L Mulvagh

  • 1Department of Surgery, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA. miller.virginia@mayo.edu

Trends in Pharmacological Sciences
|May 1, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Women's heart centres: a clinical consensus statement of the European Association of Cardiovascular Imaging (EACVI), the European Association of Percutaneous Cardiovascular Interventions (EAPCI), the Heart Failure Association (HFA), and the Association for Acute CardioVascular Care (ACVC) of the ESC.

European heart journal·2026
Same author

Semaglutide and Cardiovascular Outcomes According to Baseline Aspirin Use: Analyses of the SOUL and SELECT Trials.

Diabetes, obesity & metabolism·2026
Same author

Oral Semaglutide and Change in Cardiovascular Risk Factors in High-Risk Type 2 Diabetes: A Post Hoc Secondary Analysis of the SOUL Randomized Clinical Trial.

JAMA cardiology·2026
Same author

Women's Cardiovascular Health and Cardiac Rehabilitation: a Priority-setting Partnership.

CJC open·2026
Same author

Sex Differences in Psychological Distress of Patients With Spontaneous Coronary Artery Dissection (SCAD): The MINDSET Study.

Circulation. Population health and outcomes·2026
Same author

Oral Semaglutide and Heart Failure Outcomes in Persons With Type 2 Diabetes: A Secondary Analysis of the SOUL Randomized Clinical Trial.

JAMA internal medicine·2026

Endothelial dysfunction, a marker for atherosclerosis, is assessed by acetylcholine-induced vasodilation. Sex hormones like estrogen and testosterone influence nitric oxide production, potentially confounding these assessments.

Area of Science:

  • Vascular biology
  • Endothelial function
  • Cardiovascular research

Background:

  • Acetylcholine infusion induces endothelium-dependent vasodilation via nitric oxide.
  • Endothelial dysfunction, the absence of vasodilation, is an early marker of atherosclerosis.
  • Assessing endothelial function is crucial for identifying at-risk individuals and treatment efficacy.

Purpose of the Study:

  • To highlight the role of endothelial function in atherosclerosis.
  • To underscore the influence of sex steroid hormones on nitric oxide production.
  • To identify potential confounding factors in endothelial function assessment.

Main Methods:

  • Intra-arterial infusion of acetylcholine to assess vasodilation.
  • Measurement of endothelium-derived relaxing factors, primarily nitric oxide.

Related Experiment Videos

  • Consideration of endogenous sex steroid hormone levels (estrogen, testosterone).

    • Main Results:

    • Acetylcholine reliably induces endothelium-dependent vasodilation mediated by nitric oxide.
    • Endothelial dysfunction correlates with early atherosclerosis.
    • Sex steroid hormones (estrogen and testosterone) enhance nitric oxide release.

    Conclusions:

    • Endothelial function assessment is vital for atherosclerosis detection and management.
    • Sex hormones significantly impact nitric oxide bioavailability.
    • Endogenous hormonal status is a critical confounding factor in endothelial function testing.