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Related Concept Videos

Association Areas of the Cortex01:21

Association Areas of the Cortex

Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
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Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
The Photochemical Reaction Center01:29

The Photochemical Reaction Center

Reaction centers are pigment-protein complexes that initiate energy conversion from photons to chemical entities. Therefore, photochemical reaction center is a more appropriate term that describes these complexes. The Nobel laureates Robert Emerson and William Arnold provided the first experimental evidence of photochemical reaction centers by demonstrating the participation of nearly 2,500 chlorophyll molecules for the release of just one molecule of oxygen. Despite thousands of photosynthetic...
Nonconscious Mimicry01:13

Nonconscious Mimicry

Nonconscious mimicry occurs when individuals alter their mannerisms to match the behaviors and expressions of those nearby, without intention.

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Related Experiment Video

Updated: Jul 15, 2026

Holistic Facial Composite Creation and Subsequent Video Line-up Eyewitness Identification Paradigm
09:49

Holistic Facial Composite Creation and Subsequent Video Line-up Eyewitness Identification Paradigm

Published on: December 24, 2015

The many faces of the origin recognition complex.

Takayo Sasaki1, David M Gilbert

  • 1Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA.

Current Opinion in Cell Biology
|May 1, 2007
PubMed
Summary

The origin recognition complex (ORC) plays key roles in DNA replication and heterochromatin assembly. Emerging evidence reveals ORC

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • The origin recognition complex (ORC) is a hetero-hexameric protein complex.
  • ORC is traditionally recognized for its essential functions in DNA replication initiation and heterochromatin assembly.
  • ORC subunits have been observed in both nuclear and cytoplasmic compartments, suggesting broader cellular roles.

Purpose of the Study:

  • To explore the multifaceted roles of the origin recognition complex (ORC) beyond its canonical functions in DNA replication and heterochromatin.
  • To investigate the diverse cellular activities implicated for ORC and its subunits in both nuclear and cytoplasmic contexts.
  • To synthesize recent findings that directly implicate ORC in novel cellular processes.

Main Methods:

  • Literature review and synthesis of existing research findings.

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  • Analysis of localization and interaction data for ORC subunits.
  • Examination of experimental evidence linking ORC to specific cellular events.

    • Main Results:

    • ORC's functions in cell cycle checkpoint control and mitotic chromosome assembly may be indirectly linked to replication and heterochromatin roles.
    • Proposed roles in ribosomal biogenesis, centrosome, and kinetochore function remain inconclusive, based primarily on localization data.
    • Recent studies provide direct evidence connecting ORC to sister chromatid cohesion, cytokinesis, and neural dendritic branching.

    Conclusions:

    • The origin recognition complex (ORC) exhibits a wider range of cellular functions than previously appreciated.
    • ORC's involvement extends to crucial processes like cell division and neuronal development.
    • Further research is warranted to fully elucidate the mechanisms underlying these diverse ORC activities.