Related Experiment Video
Updated: Jul 15, 2026

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
Published on: May 6, 2010
The 4C technique: the 'Rosetta stone' for genome biology in 3D?
1Department of Development & Genetics, Norbyvägen 18A, Evolution Biology Centre, Uppsala University, S-752 36 Uppsala, Sweden. rolf.ohlsson@ebc.uu.se
Abstract:
Despite considerable efforts, the spatial link between the nuclear architecture and the genome remains enigmatic. The 4C method, independently innovated in four different laboratories, might in combination with other methods change that. As this method is based on the unbiased identification of sequences interacting with specific baits, there are unique opportunities for unravelling the secrets of how the genome functions in 3D.
Related Concept Videos
Genome Annotation and Assembly
Electron Microscope Tomography and Single-particle Reconstruction
Electron Tomography
Electron tomography can be performed either in TEM or STEM (scanning transmission...
The DNA Helix
Genomics
DNA as a Genetic Template
Evolutionary Relationships through Genome Comparisons

