Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jul 15, 2026

Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study

Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study

Published on: June 29, 2016

PSA-NCAM expression in the human prefrontal cortex.

Emilio Varea¹, Esther Castillo-Gómez, María Angeles Gómez-Climent

¹Neurobiology Unit and Program in Basic and Applied Neurosciences, Cell Biology Department, Universitat de València, Dr. Moliner 50, Burjassot 46100, Spain.

Journal of Chemical Neuroanatomy

|May 1, 2007

Summary

Polysialylated neural cell adhesion molecule (PSA-NCAM) is found in the human prefrontal cortex (PFC), similar to rodents. This molecule may play a role in PFC structural plasticity relevant to psychiatric disorders.

Related Concept Videos

Association Areas of the Cortex

Association Areas of the Cortex

Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Depletion of Neurocan in the Prefrontal Cortex Impairs Temporal Order Recognition, Cognitive Flexibility and Perisomatic GABAergic Innervation.

Cellular and molecular neurobiology·2026

Same author

Corrigendum to "Erythropoietin targets parvalbumin-positive inhibitory neurons and microglia to promote plasticity in the thalamic reticular nucleus" [Neuropharmacology 297 (2026) 111025].

Neuropharmacology·2026

Same author

Erythropoietin targets parvalbumin-positive inhibitory neurons and microglia to promote plasticity in the thalamic reticular nucleus.

Neuropharmacology·2026

Same author

Perisomatic innervation on the semilunar granule cells and outer molecular layer granule cells of the dentate gyrus of the mouse.

Frontiers in neuroanatomy·2026

Same author

Correction: Cost-Effectiveness Analysis of Sequential Treatment Strategies for Moderate to Severe Crohn's Disease in Spain: Where Should Biosimilar Ustekinumab Be Positioned?

PharmacoEconomics - open·2026

Same author

Aggression after intermittent ethanol intoxication in mice: Sex differences and modulation via medial amygdala relaxin-3/RXFP3 signaling.

Neuropharmacology·2026

Area of Science:

Neuroscience
Cellular Biology

Background:

The adult prefrontal cortex (PFC) exhibits neuronal remodeling, implicated in psychiatric disorders.
Cellular mechanisms of PFC plasticity remain unclear.
Polysialylated neural cell adhesion molecule (PSA-NCAM) influences neurite outgrowth and synaptogenesis.

Purpose of the Study:

Investigate PSA-NCAM expression in the human PFC.
Determine the cellular localization of PSA-NCAM in the human PFC.
Compare human PFC PSA-NCAM expression to rodent models.

Main Methods:

Immunohistochemistry on human PFC tissue (rostromedial superior frontal gyrus).
Analysis of PSA-NCAM expression patterns.
Identification of PSA-NCAM-expressing cell populations using markers like doublecortin and calbindin.

Related Experiment Videos

Last Updated: Jul 15, 2026

Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study

Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study

Published on: June 29, 2016

Main Results:

PSA-NCAM is expressed in the human PFC neuropil in a laminated pattern.
PSA-NCAM is found in a subpopulation of mature neurons lacking doublecortin.
Most PSA-NCAM-expressing neurons identified as calbindin-positive interneurons.
Human PFC PSA-NCAM expression pattern resembles that in rodents.

Conclusions:

PSA-NCAM is expressed in the human PFC, similar to rodents.
PSA-NCAM may contribute to structural plasticity in the human PFC.
Given its link to depression models, PSA-NCAM could be involved in PFC changes in depressed patients.