Harnessing bioinformatics to discover new vaccines
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Updated: Jul 15, 2026

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes
Published on: March 25, 2014
Matthew N Davies1, Darren R Flower
1The Jenner Institute, University of Oxford, Compton, Berkshire, RG20 7NN, UK.
Abstract:
Vaccine design is highly suited to the application of in silico techniques, for both the discovery and development of new and existing vaccines. Here, we discuss computational contributions to epitope mapping and reverse vaccinology, two techniques central to the new discipline of immunomics. Also discussed are methods to improve the efficiency of vaccination, such as codon optimization and adjuvant discovery in addition to the identification of allergenic proteins. We also review current software developed to facilitate vaccine design.
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