Born too soon: the continuing challenge of preterm labor and birth in the United States

Nancy Jo Reedy1

  • 1Nurse-Midwifery Services, Texas Health Care, PLLC, Fort Worth, TX 76104, USA. texascnm@gmail.com

Insights

Preterm birth remains a major obstetric challenge, impacting families and healthcare systems long-term. New data suggests even late preterm infants (34-37 weeks) face greater risks than previously understood.

Area of Science:

  • Obstetrics and Gynecology
  • Neonatal Medicine
  • Public Health

Background:

  • Prematurity is a leading cause of infant morbidity and mortality.
  • Current prevention and intervention strategies have not significantly reduced preterm birth rates.
  • Late preterm infants (34-37 weeks) may be at higher risk than previously recognized.

Purpose of the Study:

  • To review evidence-based strategies for risk identification in preterm labor.
  • To outline current prevention methods for preterm birth.
  • To discuss management approaches for women experiencing preterm labor and birth.

Main Methods:

  • Review of existing literature on preterm birth risk factors.
  • Analysis of evidence-based prevention and management guidelines.
  • Synthesis of recent data on late preterm infant outcomes.

Main Results:

  • Preterm birth significantly impacts individuals, families, and healthcare systems throughout life.
  • Despite efforts, the incidence of preterm birth remains a persistent challenge.
  • Infants born between 34 and 37 weeks' gestation may face more substantial long-term risks.

Conclusions:

  • Effective identification, prevention, and management of preterm labor are crucial.
  • Further research is needed to understand and mitigate risks associated with late preterm birth.
  • Addressing prematurity requires a comprehensive approach across healthcare and societal levels.

Related Concept Videos

Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Fetal Circulation01:14

Fetal Circulation

Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Development of the Oral Microbiota01:28

Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Nature and Nurture01:10

Nature and Nurture

Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience, such as differences...