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Ocular thrombosis associated with antiphospholipid antibodies
S L Galetta1, G L Plock, M J Kushner
1Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia.
Annals of Ophthalmology
|June 1, 1991
Summary
Antiphospholipid antibodies may cause ocular ischemic syndromes through small vessel thrombosis. This study highlights a potential mechanism for vision loss in patients with these antibodies.
Area of Science:
- Ophthalmology
- Rheumatology
- Vascular Medicine
Background:
- Antiphospholipid antibodies are associated with an increased risk of thrombosis.
- Ocular ischemic syndromes can lead to significant vision loss.
Observation:
- Four patients presented with acute ocular ischemic syndromes.
- All four patients had circulating antiphospholipid antibodies.
- Two patients experienced vaso-occlusive retinopathy, and two had anterior ischemic optic neuropathy.
Findings:
- Two patients had identifiable vascular risk factors: essential thrombocytosis and hypertension with coronary artery disease.
- Small vessel thrombosis in situ is suggested as a mechanism for these ischemic events.
Implications:
- This suggests a potential link between antiphospholipid antibodies and ocular ischemia via thrombosis.
- Early identification of antiphospholipid antibodies may be crucial in managing ocular ischemic events.
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