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No increased risk of relapse after meningococcal C conjugate vaccine in nephrotic syndrome

Brent Taylor1, Nick Andrews, Julia Stowe

  • 1General and Adolescent Paediatric Unit, Institute of Child Health, University College London, London, UK.

Archives of Disease in Childhood
|May 1, 2007
PubMed

Insights

Meningococcal C conjugate vaccine (MCCV) did not increase the risk of relapse in children with steroid-responsive nephrotic syndrome. These findings indicate that MCCV is not a contraindication for children with this condition.

Area of Science:

  • Pediatric Nephrology
  • Vaccinology
  • Epidemiology

Background:

  • Steroid-responsive nephrotic syndrome (SRNS) is a common kidney disease in children.
  • Concerns exist regarding potential vaccine-induced relapses in children with SRNS.
  • Meningococcal C conjugate vaccine (MCCV) is widely used in childhood immunization programs.

Purpose of the Study:

  • To determine if MCCV administration is associated with an increased risk of relapse in children diagnosed with SRNS.
  • To evaluate the safety of MCCV in the context of SRNS management.

Main Methods:

  • A population-based study utilizing an active surveillance system to track adverse events post-vaccination.
  • Ecological study analyzing hospital admissions for nephrotic syndrome before and after MCCV introduction in England and Wales (1995-2003).
  • Self-controlled case series analysis and incidence rate ratios were employed to assess relapse risk and admission rates.

Main Results:

  • The self-controlled case series analysis revealed no increased risk of relapse following MCCV administration (relative incidence 0.95, 95% CI 0.61-1.47).
  • The ecological study showed no significant change in nephrotic syndrome admission rates after MCCV introduction (incidence rate ratio 1.05, 95% CI 0.95-1.15).

Conclusions:

  • There is no observed association between MCCV and nephrotic syndrome relapses in children.
  • Meningococcal C conjugate vaccine (MCCV) is considered safe and not a contraindication for children with steroid-responsive nephrotic syndrome.
Abstract

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