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Related Experiment Videos

Infectious keratitis in Baltimore.

J C Wahl1, H R Katz, D A Abrams

  • 1Sinai Hospital of Baltimore, MD 21215.

Annals of Ophthalmology
|June 1, 1991
PubMed
Summary

This study on ulcerative keratitis found Staphylococcus epidermidis and Pseudomonas aeruginosa as common causes. Pseudomonas aeruginosa was more frequent in contact lens wearers, suggesting specific pathogen risks.

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Effect of topical ciprofloxacin 0.3% and ofloxacin 0.3% on the reduction of bacterial flora on the human conjunctiva.

Journal of cataract and refractive surgery·2000

Area of Science:

  • Ophthalmology
  • Microbiology

Background:

  • Ulcerative keratitis is a significant cause of vision loss.
  • Identifying causative pathogens is crucial for effective treatment.

Purpose of the Study:

  • To review cases of ulcerative keratitis and identify common microbial isolates.
  • To investigate the association between corneal and conjunctival cultures.
  • To evaluate the utility of Gram stains and conjunctival cultures.

Main Methods:

  • Retrospective review of 130 ulcerative keratitis cases (1985-1989).
  • Analysis of corneal, conjunctival, and eyelid margin cultures.
  • Correlation of isolates with patient history, including contact lens wear.

Main Results:

  • 40% of cases yielded positive corneal cultures.
  • Staphylococcus epidermidis (28%), S. aureus (16%), and Pseudomonas aeruginosa were most common.
  • P. aeruginosa was prevalent in contact lens wearers.
  • A significant association (P = .05) was found between corneal and ipsilateral conjunctival isolates.
  • Gram stains were consistently negative.

Conclusions:

  • Common pathogens in ulcerative keratitis include S. epidermidis, S. aureus, and P. aeruginosa.
  • Conjunctival cultures may provide useful diagnostic information.
  • The routine use of Gram stains for ulcerative keratitis may be limited.

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