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Serum leptin levels in obese Indian children relation to clinical and biochemical parameters

Sudhisha Dubey1, Madhulika Kabra, Anurag Bajpai

  • 1Genetic Unit, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi 110 029, India.

Indian Pediatrics
|May 1, 2007
PubMed

Insights

Serum leptin levels are elevated in obese Indian children and correlate with obesity indicators and adverse lipid profiles. Further research is needed to understand leptin's role in childhood obesity and metabolic syndrome.

Area of Science:

  • Endocrinology
  • Pediatrics
  • Metabolic Research

Background:

  • Childhood obesity is a growing global health concern.
  • Leptin, a key hormone in energy balance, is implicated in obesity.
  • Understanding leptin's role in obese Indian children is crucial for targeted interventions.

Purpose of the Study:

  • To evaluate serum leptin levels in obese Indian children.
  • To assess the correlation between leptin levels and anthropometric measurements.
  • To investigate the association of leptin with biochemical parameters in obese children.

Main Methods:

  • A cohort study was conducted at a referral tertiary hospital.
  • Serum leptin levels were measured in obese children and adults, and compared to normal-weight controls.
  • Anthropometric (BMI, waist circumference, waist-to-hip ratio) and biochemical (lipids, glucose) parameters were analyzed.

Main Results:

  • Obese Indian children and adults exhibited significantly higher serum leptin levels compared to controls.
  • Leptin levels were higher in obese girls and women than in their male counterparts.
  • Serum leptin showed significant positive correlations with BMI, waist circumference, waist-to-hip ratio, cholesterol, triglycerides, and LDL-cholesterol.

Conclusions:

  • Serum leptin levels are significantly associated with anthropometric and lipid profiles in obese Indian children.
  • These findings highlight the potential role of leptin in the pathophysiology of childhood obesity.
  • Further research is warranted to explore leptin's involvement in metabolic syndrome development in this population.
Abstract

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