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Updated: Jul 15, 2026

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
05:53

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Published on: July 6, 2013

Valganciclovir for congenital CMV infection: a pilot study on plasma concentration in newborns and infants

Luisa Galli1, Andrea Novelli, Elena Chiappini

  • 1Departments of Pediatrics, University of Florence, Florence, Italy.

The Pediatric Infectious Disease Journal
|May 1, 2007
PubMed

Insights

Valganciclovir pharmacokinetics were analyzed in 8 infants aged 4 to 90 days. A dosage of 15 mg/kg twice daily may be appropriate for neonates and young infants.

Area of Science:

  • Pediatric pharmacology
  • Antiviral drug pharmacokinetics

Background:

  • Valganciclovir is a crucial antiviral medication for treating cytomegalovirus infections in infants.
  • Understanding its pharmacokinetic profile in neonates and young infants is essential for safe and effective dosing.

Purpose of the Study:

  • To investigate the pharmacokinetics of valganciclovir in a cohort of infants.
  • To determine a potentially suitable dosage regimen for this population.

Main Methods:

  • Pharmacokinetic analysis of valganciclovir.
  • Study conducted on 8 infants aged 4 to 90 days.

Main Results:

  • The study characterized valganciclovir pharmacokinetics in infants.
  • Preliminary data suggest a potential dosing regimen.

Conclusions:

  • A dosage of 15 mg/kg administered twice daily is proposed as potentially suitable for neonates and young infants.
  • Further studies may be warranted to confirm these findings.

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