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Published on: May 5, 2018
Maternal hemodynamic changes associated with furosemide treatment
Darcy B Carr1, Daniel Gavrila, Debra Brateng
1Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, WA, USA. darcarr@u.washington.edu
Objective:
To assess the pharmacodynamic effects of furosemide in pregnancy.
Methods:
Twenty-one pregnant women who received furosemide 20 mg daily had cardiac output (CO), stroke volume (SV), and total peripheral resistance (TPR) measured by Doppler technique before and after treatment.
Results:
Furosemide was initiated at 22.4 +/- 6.0 weeks gestation. CO and SV decreased (mean +/- SD: 1.2 +/- 0.2 L/min and 17+/-3 mL, respectively), whereas TPR increased (101+/-26 dyne.sec.cm(-5); p < 0.001 for all) after 2.9+/-1.4 weeks. Hemodynamics did not approach the expected mean for pregnancy.
Conclusions:
While furosemide improved the hyperdynamic circulation in pregnancy, it did not lower blood pressure or cause clinically significant vasoconstriction.
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