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Updated: Jul 15, 2026
The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
Published on: August 2, 2017
The effect of mode of delivery on placental chorionic plate vascular reactivity
Tracey A Mills1, Philip N Baker, Mark Wareing
1Division of Human Development, The University of Manchester, Manchester, UK. tracey.mills@manchester.ac.uk
Objective:
To determine whether delivery mode influences placental chorionic plate arterial and venous vascular reactivity.
Methods:
Normal term placentas were obtained after vaginal delivery or cesarean section. Chorionic plate arterial and venous function was assessed by wire myography.
Results:
Sodium nitroprusside-induced arterial relaxation increased post cesarean section at 20% oxygen. Decreased U46619-induced venous contraction was observed in vaginal deliveries at 7% oxygen. Sodium nitroprusside-induced relaxation increased in vaginal delivery at 20% oxygen.
Conclusion:
Delivery mode does not alter chorionic plate arterial vascular reactivity under physiological conditions, however venous reactivity was modified, a factor for consideration when interpreting functional experimental data.
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