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Where did the super-small sized large bowel advanced cancer come from?

Ryo Wada1, Koichi Sato, Takafumi Ichida

  • 1Department of Pathology, Juntendo Shizuoka Hospital of Juntendo University School of Medicine, Shizuoka, Japan. mdksmrwjunten522@ybb.ne.jp

Journal of Carcinogenesis
|May 2, 2007
PubMed

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...