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Related Experiment Video

Updated: Jul 15, 2026

Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit

Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit

Published on: August 2, 2017

Hippocampal place cell assemblies are speed-controlled oscillators.

Caroline Geisler¹, David Robbe, Michaël Zugaro

¹Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, NJ 07102, USA.

Proceedings of the National Academy of Sciences of the United States of America

|May 2, 2007

Summary

Hippocampal place cells exhibit phase precession, a phenomenon crucial for spatial coding. This study reveals that faster running speeds accelerate cell oscillations, maintaining consistent phase-distance relationships.

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Last Updated: Jul 15, 2026

Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit

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Published on: August 2, 2017

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

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Published on: June 29, 2018

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice

Published on: July 1, 2018

Area of Science:

Neuroscience
Computational Neuroscience
Systems Neuroscience

Background:

Hippocampal pyramidal cells display phase precession, where spike timing shifts relative to theta oscillations as animals traverse place fields.
The spatial-phase precession relationship is invariant to running speed, a critical feature for spatial memory and hippocampal function, but its underlying mechanism remains unclear.

Purpose of the Study:

To investigate the mechanism behind the speed-invariant spatial-phase precession of hippocampal place cells.
To explore how changes in running speed affect place cell activity and theta oscillations.

Main Methods:

Analysis of spike timing and local field potential theta oscillations in hippocampal pyramidal cells and interneurons.
Comparison of phase precession dynamics at different animal running speeds.

Main Results:

Faster running speeds lead to fewer active theta cycles per place field traversal.
Place cells exhibit higher oscillation frequencies and increased spike rates per cycle at faster speeds.
While the temporal precession slope accelerates with speed, the spatial-phase precession remains invariant.

Conclusions:

The speed-correlated acceleration of place cell assembly oscillations is hypothesized to be the mechanism underlying the speed-invariant spatial-phase precession.
Interneurons may contribute to forming coherently precessing cell assemblies, further supporting spatial coding.