Related Experiment Video
Updated: Jul 15, 2026

A Pre-Clinical Model of Synovitis Using Ex vivo Human Synovial Tissue with Preserved Function and Architecture
Published on: March 20, 2026
The molecular and cellular aspects of arthritis due to alphavirus infections: lesson learned from Ross River virus
Nestor E Rulli1, Julian Melton, Anja Wilmes
1Centre for Virus Research, School of Health Sciences, University of Canberra, Canberra, ACT, Australia.
Abstract:
Alphaviruses such as the Sindbis-group viruses, Scandinavian Ockelbo virus, the African Asian chikungunya virus, the African O'nyong-nyong virus, the South American Mayaro virus, and the Australasian Barmah Forest and Ross River viruses, are commonly associated with outbreaks of acute and persistent arthritis and arthralgia in humans. The mechanisms by which these viruses cause arthritis/arthralgia are poorly understood. This chapter summarizes our current understanding of viral arthritides using our newly developed mouse model of Ross River virus-induced joint and muscle inflammation.
Related Concept Videos
Arboviral Encephalitis
Rabies
Viruses of Archaea
The JAK-STAT Signaling Pathway
Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

