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Updated: Jul 15, 2026

Activating Autophagy by Aerobic Exercise in Mice
Published on: February 3, 2017
AMPK mediates autophagy during myocardial ischemia in vivo
Hiromitsu Takagi1, Yutaka Matsui, Shinichi Hirotani
1Cardiovascular Research Institute, Department of Cell Biology and MolecularMedicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA.
Abstract:
We have recently shown that autophagy is induced by ischemia and reperfusion in the mouse heart in vivo. Ischemia stimulates autophagy through an AMP activated protein kinase (AMPK)-dependent mechanism, whereas reperfusion after ischemia stimulates autophagy through a Beclin 1-dependent, but AMPK-independent, mechanism. Autophagy plays distinct roles during ischemia and reperfusion: autophagy may be protective during ischemia, whereas it may be detrimental during reperfusion. We will discuss the role of AMPK in mediating autophagy during myocardial ischemia in vivo.
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