Cerebral cortical blood flow response during basal forebrain stimulation in cats

We examined whether stimulation of the basal forebrain affects regional cerebral blood flow in the primary somatosensory cortex in cats. In anesthetized cats with spinal cord transection at the T1 level, focal electrical stimulation of the unilateral basal forebrain increased the blood flow of the ipsilateral primary somatosensory cortex that was increased by stimulation of the contralateral forepaw, without any change in blood pressure. The response was the largest when the tip of the electrode was located within the area known to contain the basal forebrain neurons projecting to the primary somatosensory cortex. These results suggest that basal forebrain neurons projecting to the primary somatosensory cortex have a vasodilative function in cats, as previously found in rats.