Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Movement of Organelles and Vesicles

The Movement of Organelles and Vesicles

In eukaryotic cells, cytoskeletal filaments such as actin, microtubules, and intermediate filaments form a mesh-like cytoskeletal network. These filaments serve as tracks for transporting cellular cargo. Specialized motor proteins use the chemical energy stored in adenosine triphosphate (ATP) for this transport. During interphase, microtubules are polarized, with the plus-end towards the cell periphery and the minus-end towards the cell center. Two microtubule-associated motor proteins,...

Introduction to the Cytoskeleton

Introduction to the Cytoskeleton

Overview of the Cytoskeleton
The cytoskeleton is a network of protein filaments present within the cell, having three distinct filaments ̶ microfilaments, microtubules, and intermediate filaments. Each has characteristic features that distinguish them, including the dynamics of their assembly and disassembly, mechanical properties, polarity, and the type of molecular motors associated with them. Earlier, they were thought to be present only in eukaryotic cells; however, their homologs were...

Cytoplasm

Cytoplasm

The cytoplasm consists of organelles and a framework of protein scaffolds called the cytoskeleton suspended in an aqueous solution, the cytosol. The cytosol is a rich broth of water, ions, salts, and various organic molecules.
Protein Folding and Misfolding
The cytoplasm is the location for several cellular processes, including protein synthesis and folding. The aqueous nature of the cytosol promotes protein folding such that the hydrophobic amino acid side chains are buried in the protein...

Cytoplasm

Cytoplasm

The cytoplasm consists of organelles and a framework of protein scaffolds called the cytoskeleton suspended in an aqueous solution, the cytosol. The cytosol is a rich broth of water, ions, salts, and various organic molecules.Protein Folding and MisfoldingThe cytoplasm is the location for several cellular processes, including protein synthesis and folding. The aqueous nature of the cytosol promotes protein folding such that the hydrophobic amino acid side chains are buried in the protein core...

Adaptability of Cytoskeletal Filaments

Adaptability of Cytoskeletal Filaments

The cytoskeleton is a complex dynamic structure performing varied functions based on cellular requirements. The adaptability of the individual filaments in the cytoskeleton determines their ability to perform various functions within the cell. It can undergo rapid reorganization during processes like cell division or remain stable for several hours as in the interphase. The adaptability of these filaments depends on stringent regulatory mechanisms. The microfilament and microtubules of the...

Microtubules

Microtubules

There are three types of cytoskeletal structures in eukaryotic cells—microfilaments, intermediate filaments, and microtubules. With a diameter of about 25 nm, microtubules are the thickest of these fibers. Microtubules carry out a variety of functions that include cell structure and support, transport of organelles, cell motility (movement), and the separation of chromosomes during cell division.Microtubules are hollow tubes whose walls are made up of globular tubulin proteins. Each tubulin...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Age-related changes and lack of effect of midlife resistance wheel exercise on afferent connectivity of lumbar alpha motor neurons in ageing mouse spinal cord.

Biogerontology·2025

Same author

Unlocking deep relaxation: the power of rhythmic breathing on brain rhythms.

Npj mental health research·2025

Same author

Planning Feasibility of an ENT (Otorhinolaryngology) Daycare Surgical Unit with Reference to Return on Investment.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India·2025

Same author

Differential Expression of Splicing Factor Gene by Estrogen Receptor Activation Factor.

Molecular reproduction and development·2025

Same author

Transcriptional Landscape of Repetitive Elements in Psoriatic Skin from Large Cohort Studies: Relevance to Psoriasis Pathophysiology.

International journal of molecular sciences·2023

Same author

Effects of Sudarshan KriyaYoga and Advanced Meditation Program on Genetic Expression of Pro-inflammatory and Antioxidants Genes.

Cureus·2023

Search research articles

Related Experiment Video

Updated: Jul 15, 2026

Visualizing and Analyzing Intracellular Transport of Organelles and Other Cargos in Astrocytes

Visualizing and Analyzing Intracellular Transport of Organelles and Other Cargos in Astrocytes

Published on: August 28, 2019

Cytoskeletal elements and intracellular transport.

Lakshmi Bhaskar¹, Vidya S Krishnan, Raghava Varman Thampan

¹Department of Industrial Microbiology, Govt. College for Women, Vazhuthacaud, Trivandrum 695014, Kerala, India.

Journal of Cellular Biochemistry

|May 2, 2007

Summary

Cytoskeletal elements, including actin and microtubules, regulate intracellular protein transport. These networks coordinate motor proteins to influence protein dynamics and the movement of steroid receptors.

More Related Videos

Immobilization of Caenorhabditis elegans to Analyze Intracellular Transport in Neurons

Immobilization of Caenorhabditis elegans to Analyze Intracellular Transport in Neurons

Published on: October 18, 2017

Related Experiment Videos

Last Updated: Jul 15, 2026

Visualizing and Analyzing Intracellular Transport of Organelles and Other Cargos in Astrocytes

Visualizing and Analyzing Intracellular Transport of Organelles and Other Cargos in Astrocytes

Published on: August 28, 2019

Immobilization of Caenorhabditis elegans to Analyze Intracellular Transport in Neurons

Immobilization of Caenorhabditis elegans to Analyze Intracellular Transport in Neurons

Published on: October 18, 2017

Area of Science:

Cell Biology
Molecular Biology
Biochemistry

Background:

The cytoskeleton, traditionally viewed for structure, is increasingly recognized for its role in intracellular transport.
Cooperative interactions exist between actin and microtubule cytoskeletons, involving various motor protein families.
Intermediate filaments also participate in specific intracellular transport processes.

Purpose of the Study:

To explore the regulatory role of cytoskeletal elements in intracellular protein transport.
To investigate the functional overlap and coordination between actin and microtubule networks in protein transport.
To specifically examine the involvement of actin in the intracellular transport of steroid receptors and related proteins.

Main Methods:

Review of recent advances in cytoskeleton research.
Analysis of studies on motor protein involvement in cytoskeletal dynamics.
Focus on literature concerning steroid receptor transport mechanisms.

Main Results:

Cytoskeletal elements actively regulate the transport of numerous cellular proteins.
Actin and microtubule cytoskeletons exhibit cooperative interactions and functional overlap in transport.
Multiple motor proteins are implicated in controlling protein dynamics and coordination.

Conclusions:

The cytoskeleton plays a crucial, dynamic role in intracellular protein trafficking beyond structural support.
Coordinated action of different motor proteins is essential for regulating protein transport dynamics.
Actin, in particular, is significantly involved in the intracellular transport of steroid receptors and associated proteins.