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Related Concept Videos

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Ultrasound II: Endoscopic Ultrasound and FibroScan01:25

Ultrasound II: Endoscopic Ultrasound and FibroScan

Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...

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Neuroendocrine Liver Metastasis: Transplant as Part of Multimodality Liver-Directed Therapy-Reply.

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Related Experiment Video

Updated: Jul 15, 2026

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
08:41

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

Published on: March 24, 2023

Nonalcoholic fatty liver disease.

Paul Angulo1

  • 1Division of Gastroenterology & Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. angulohernandez.paul@mayo.edu

Revista De Gastroenterologia De Mexico
|May 3, 2007
PubMed
Summary

Nonalcoholic fatty liver disease (NAFLD) affects many, worsening insulin resistance and increasing mortality risk. Lifestyle changes are key, but new therapies are needed for progressive liver disease.

Area of Science:

  • Hepatology
  • Metabolic Syndrome
  • Internal Medicine

Background:

  • Nonalcoholic fatty liver disease (NAFLD) is highly prevalent, particularly in individuals with obesity and diabetes.
  • Insulin resistance is a central factor in NAFLD pathogenesis, leading to hepatic fat accumulation.
  • NAFLD can worsen hepatic insulin resistance, potentially preceding glucose intolerance and contributing to liver damage.

Purpose of the Study:

  • To review the pathogenesis, diagnosis, and clinical implications of NAFLD.
  • To highlight the association between NAFLD, insulin resistance, and metabolic risk factors.
  • To discuss current management strategies and the need for further research.

Main Methods:

  • Review of existing literature on NAFLD.

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In Vitro Modeling of Fat Deposition in Metabolic Dysfunction-Associated Steatotic Liver Disease
07:03

In Vitro Modeling of Fat Deposition in Metabolic Dysfunction-Associated Steatotic Liver Disease

Published on: July 19, 2024

Related Experiment Videos

Last Updated: Jul 15, 2026

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
08:41

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

Published on: March 24, 2023

In Vitro Modeling of Fat Deposition in Metabolic Dysfunction-Associated Steatotic Liver Disease
07:03

In Vitro Modeling of Fat Deposition in Metabolic Dysfunction-Associated Steatotic Liver Disease

Published on: July 19, 2024

  • Analysis of pathogenic mechanisms including insulin resistance, oxidative stress, and inflammation.
  • Discussion of diagnostic methods (imaging vs. biopsy) and staging.

    • Main Results:

    • NAFLD is linked to increased all-cause mortality, vascular disease, cirrhosis, and hepatocellular carcinoma.
    • NAFLD is a significant contributor to cases previously diagnosed as 'cryptogenic cirrhosis'.
    • Obesity, diabetes, and non-alcoholic steatohepatitis (NASH) are risk factors for disease progression.

    Conclusions:

    • NAFLD is a complex condition with significant metabolic and hepatic consequences.
    • Weight loss and exercise are primary treatments, with insulin-sensitizing agents showing promise.
    • Further research is crucial to personalize NAFLD therapies and identify high-risk patients.