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Published on: December 28, 2021

[Cernilton in the treatment of prostatic adenoma and chronic prostatitis]

E G Aslamazov, N D Akhvlediani, A Z Vinarov

    Urologiia (Moscow, Russia : 1999)
    |May 3, 2007
    PubMed

    Insights

    Cernilton effectively treats prostatic adenoma (PA) and chronic bacterial prostatitis (CBP). It significantly improves urinary symptoms, quality of life, and key prostate health indicators in PA patients and aids CBP treatment.

    Area of Science:

    • Urology
    • Pharmacology

    Background:

    • Prostatic adenoma (PA) and chronic bacterial prostatitis (CBP) are common conditions affecting men's lower urinary tract health.
    • Current treatments for PA and CBP have limitations, necessitating exploration of alternative therapies.

    Purpose of the Study:

    • To evaluate the efficacy of cernilton in treating PA and CBP.
    • To compare cernilton's effectiveness as monotherapy for PA and in combination with antibiotics for CBP.

    Main Methods:

    • A study involving three groups: PA patients (n=31) treated with cernilton, CBP patients (n=32) treated with antibiotics and cernilton, and CBP patients (n=30) treated with antibiotics only.
    • Patients were assessed using the International Prostate Symptom Score (IPSS), prostate-specific antigen (PSA) levels, maximum urinary flow rate (Qmax), prostate volume (Vprost), and residual volume (Vres).
    • CBP patients were also evaluated using the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI).

    Main Results:

    • Cernilton monotherapy in PA patients led to significant improvements in IPSS, quality of life, Qmax, and reductions in Vprost and Vres (p < 0.001).
    • Serum PSA levels decreased by 21.2% in PA patients treated with cernilton.
    • In CBP patients, combination therapy with cernilton and antibiotics (group IIa) showed greater improvement in pain, dysuria, quality of life, Qmax, Vres, and Vprost compared to antibiotic monotherapy (group IIb) (p < 0.05).

    Conclusions:

    • Cernilton demonstrates significant efficacy as a monotherapy for prostatic adenoma.
    • Cernilton is effective when used in combination with antibiotics for treating chronic bacterial prostatitis.
    • The findings support cernilton as a valuable therapeutic option for both PA and CBP.

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