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Effects of polydipsia-hyponatremia on seizures in patients with epilepsy
Mitsutoshi Okazaki1, Masumi Ito, Masaaki Kato
1Department of Psychiatry, National Center of Neurology and Psychiatry, Musashi Hospital, Kodaira, Tokyo, Japan. okazakim@ncnp.go.jp
Abstract:
Aggravation of seizures due to hyponatremia was investigated in five patients with epilepsy and polydipsia-hyponatremia. They experienced marked increases in the frequency of their complex partial seizures with a decrease in the serum sodium level to 118-127 mEq/L. In all cases, the serum sodium level returned to normal through restriction of fluids, and the clinical seizures improved. All patients had shown intellectual impairment and/or psychotic episodes, and all had been given antipsychotics. Hyponatremia caused by polydipsia appears to be a risk factor for aggravation of habitual seizures in patients with epilepsy.
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