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Related Experiment Videos

[Antithrombin III. Physiologic, physiopathologic and laboratory aspects].

J C de Sousa1, R Ferreira, F Carriço

  • 1Serviço de Patologia Clínica, Hospital de Santa Maria, Lisboa.

Revista Portuguesa De Cardiologia : Orgao Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
|September 1, 1991
PubMed
Summary

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Antithrombin III (ATIII) deficiency causes thrombosis and reduces heparin effectiveness. This review covers ATIII biology, deficiency implications, and laboratory diagnostics for effective heparin therapy and thrombosis management.

Area of Science:

  • Biochemistry and Physiology
  • Hematology
  • Pharmacology

Context:

  • Hemostasis relies on a balance between coagulation activators and inhibitors.
  • Plasma Antithrombin III (ATIII) is a key inhibitor crucial for heparin's therapeutic effect.
  • ATIII deficiency is linked to thrombotic states and impaired heparin efficacy.

Purpose:

  • To review the biology of Antithrombin III (ATIII).
  • To analyze the implications of ATIII deficiency in thrombosis and heparin therapy.
  • To describe laboratory methods for ATIII assessment and heparin therapy monitoring.

Summary:

  • This review details the biochemical nature, physiology, pathophysiology, and mechanism of action of ATIII.
  • It examines the prevalence and clinical significance of congenital and acquired ATIII deficiency in relation to venous thrombosis.

Related Experiment Videos

  • The study emphasizes the role of ATIII concentrates and discusses heparin resistance.

    • Impact:

    • Highlights the importance of understanding ATIII in managing thrombotic disorders.
    • Provides insights into optimizing heparin therapy through ATIII level monitoring.
    • Informs clinical practice regarding diagnosis and treatment of ATIII-related coagulation disorders.